ABSTRACT
The aim of the present investigation was to compare the healing process of repaired Achilles tendons of healthy rats and streptozotocin induced diabetic [STZ-D] rats by evaluating strength and toughness of repaired tendons via tensiometrical test. 14 healthy male adult rat were divided into control [n=6] and experimental rats [n=8]. Type 1 diabetes was induced in experimental rats by an injection of 55 mg/kg STZ intraperitoneally. Control rats were received distilled water. Blood Sugar of all rats was recorded after seven days. Animals of experimental group that failed to develop average blood glucose concentration greater than 250mg/dc were excluded from the study. Right Achilles tendon of all rats was transected completely 30 days after STZ injection. Repairing Achilles tendons were extracted and were submitted to a tensiometerical examination10 days after surgery. Data were compared by student t test. Independent sample t test analysis showed that Young's modulus of elasticity [18.5 +/- 12.1MPa/mm] and stress high load [3.04 +/- 1.38, MPa/mm] of control group were significantly higher than those of experimental group [2.5 +/- 2 and 0.975 +/- 0.269 respectively], [p=0.003 and p=0.004 respectively]. It is concluded that induction of type one diabetes by STZ in rats after 30 days reduced significantly tensiometrical parameters of repairing Achilles tendon in comparison with control rats